Seen that trailer, it does look great. Hopefully it's a little more mature and challenging than Fallout 3, more like Fallout: New Vegas. A hardcore mode with hunger, sleep etc makes the game better and fits the setting. That said my pants are bulging in anticipation.
Right now Skyrim is getting a bit old, but ESO just released as free to play. Also since FO4 is coming this year I can't see an Elder Scrolls 6 game being out earlier than 2016 (prob will be 2016). Bethesda won't compete with themselves, and they likely use the same artists/coders, so would be transitioning staff from FO4 to ES6 now that FO4 almost done.
Dishonoured was a really fun game, but only if you played it as stealth. It would have been more fun without the silly black and white morality system though.